New neurons follow the flow of cerebrospinal fluid in the adult brain.
نویسندگان
چکیده
In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
منابع مشابه
Cerebrospinal Pulsation Hydrodynamics in a 2D Simulation of Brain Ventricles
In this article, dynamics of the cerebrospinal fluid (CSF) was studied, using computational fluid dynamics. Using MRI images of two special cases, a 2-dimensional model of the ventricular system was made. CSF velocity and pressure distribution in ventricular system have high importance since the flow pattern of this liquid has an important effect on intracranial pressure, i.e., ICP, which has a...
متن کاملمدلسازی عددی هیپوترمی مغزی با استفاده از سرد کردن مایع مغزی-نخاعی
Background: Brain hypothermia by reducing the temperature of the cerebrospinal fluid is done by a cooling pad in the thoracic region and protect brain from the ischemic injuries. Along with the spinal cord, the brain is an essential partner in the central nervous system, and similarly, it is surrounded and protected from the bony skull and from shock by cerebrospinal fluid. The brain analyzes i...
متن کاملHigh neuronal/astroglial differentiation plasticity of adult rat hippocampal neural stem/progenitor cells in response to the effects of embryonic and adult cerebrospinal fluids
Hippocampal neural stem/progenitor cells (hipp-NS/PCs) of the adult mammalian brain are important sources of neuronal and gial cell production. In this study, the main goal is to investigate the plasticity of these cells in neuronal/astroglial differentiations. To this end, the differentiation of the hipp-NS/PCs isolated from 3-month-old Wistar rats was investigated in response to the embryonic...
متن کاملارتباط تغییرات آهن مایع مغزی نخاعی با آسیب مغز متعاقب ضربه مغزی در رت
Introduction: In Iran, thousands of young individuals become victims of head injury annually. Head injury can damage neuronal cells which may in turn complicate the recovery of the patients. Also, the increase of iron in cerebrospinal fluid (CSF) following head injury may contribute to the hypoxic-ischemia brain damage by catalyzing the formation of free radicals (Harber-Weiss Rection). The obj...
متن کاملNoradrenergic System Increases Miniature Excitatory Synaptic Currents in the Barrel Cortex
Introduction: Neurons in layer II and III of the somatosensory cortex in rats show high frequency (33 ± 13 Hz) of miniature excitatory postsynaptic currents (mEPSCs) that their rates and amplitudes are independent of sodium channels. There are some changes in these currents in neurodegenerative and psychological disorders. Regarding to well known roles of the neuromodulatory brain systems in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Science
دوره 311 5761 شماره
صفحات -
تاریخ انتشار 2006